Carboxylate Catalysis : A Catalytic O-Silylative Aldol Reaction of Aldehydes and Ethyl Diazoacetate
Finna-arvio
Carboxylate Catalysis : A Catalytic O-Silylative Aldol Reaction of Aldehydes and Ethyl Diazoacetate
A mild catalytic variant of the aldol reaction between ethyl diazoacetate and aldehydes is described using a combination of N,O-bis(trimethylsilyl)acetamide and catalytic tetramethylammonium pivalate as catalyst. The reaction proceeds rapidly at ambient temperature to afford the O-silylated aldol products in good to excellent yield, and the acetamide byproducts can be removed by simple filtration.
Tallennettuna:
Kieli |
englanti |
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Sarja | Journal of Organic Chemistry, 20 |
Aiheet | |
ISSN |
0022-3263 |