It is important to understand what drives the success of technology integration in educational settings, because learning in schools with technology develops the students' capacities to participate fully in the digital age. Educated students, in turn, can transform our societies through innovative scientific discoveries. Recently, the Technological Pedagogical Content Knowledge (TPACK) framework has emerged as a theoretical framework needed for understanding the teacher’s integration of digital technologies into teaching. Educational interactions, in turn, have been emphasized as a critical component of the educational practices, processes and contexts. However, these two concepts have been studied and developed rather independently. This paper reviews both educational interactions and the TPACK framework. Against this background, we outline and propose an integrated framework that combines two approaches and allows providing a better understanding of technology-based education, especially at the micro level of the classroom.