Catalytic Enantioselective Total Synthesis of (+)–Lycoperdic Acid
Finna-arvio
Catalytic Enantioselective Total Synthesis of (+)–Lycoperdic Acid
Revised%20Total%20Synthesis%20of%20Lycoperdic%20acid%2019032020%20clean.pdf
(Jyväskylän yliopisto - JYX)
A concise enantio- and stereocontrolled synthesis of (+)-lycoperdic acid is presented. The stereochemical control is based on iminium-catalyzed Mukaiyama–Michael reaction and enamine-catalyzed organocatalytic α-chlorination steps. The amino group was introduced by azide displacement, affording the final stereochemistry of (+)-lycoperdic acid. Penultimate hydrogenation and hydrolysis afforded pure (+)-lycoperdic acid in seven steps from a known silyloxyfuran.
Tallennettuna:
Kieli |
englanti |
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Sarja | Organic Letters, 8 |
Aiheet | |
ISSN |
1523-7060 |