Technology-mediated communication has become an integral part of work and the workplace. Since the early days of digital communication technology, views of both the affordances and uses of communication technology have become more varied and complex. Understanding the reality of communication technology at work means taking into account its ubiquitous and ever-changing nature as well as the interpersonal relationships and social networks in which it is used. This chapter explores the ways in which communication technology relates to building mutual understanding and trust as well as managing networks and coworker relationships. Knowledge of these key issues is used to present ideas about how members of the workplace can design and facilitate the use of communication technology at work.