Mechanochemical Difluoromethylations of Alcohols
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Mechanochemical Difluoromethylations of Alcohols
Difluoromethyl ethers are formed through mechanochemical reactions of alcohols with difluorocarbene in a mixer mill. The protocol could be applied to primary, secondary, and tertiary alcohols, yielding the corresponding products in excellent yields (up to 99%) after 1 h reaction time at room temperature. The transformations proceeded under solvent-free reaction conditions, followed by product purification by filtration, which drastically reduced the amount of waste generated during the process.
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Language |
English |
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Series | CCS chemistry, 8 |
Subjects | |
ISSN |
2096-5745 |